Abstract Photoacoustic imaging (PAI) can sensitively detect regions and substances with strong optical absorption, which means that diseased tissue can be imaged with high contrast in the presence of surrounding healthy tissue through the photoacoustic effect. However, its signal intensity and resolution may be limited by background signals generated...

Abstract Osteosarcoma (OS) is a “cold” tumour enriched in noninflammatory M2 phenotype tumour-associated macrophages (TAMs), which limits the efficacy of immunotherapy. The acidic tumour microenvironment (TME), generated by factors such as excess hydrogen (H+) ions and high lactate levels, activates immunosuppressive cells (e.g., M2 phenotype TAMs),...

Abstract Rapid propagation of tumor cells requires plenty of energy, which is adenosine triphosphate (ATP) dependent. ATP inhibition in tumors not only results in the starvation of tumor cells but also down-regulation of the level of heat shock proteins (HSPs), which usually increase during traditional photothermal therapy (PTT), especially when the...

Abstract Platinum is the most widespread electrode material used for implantable biomedical and neuroelectronic devices, motivating exploring ways to improve its performance and understand its fundamental properties. Using reactive magnetron sputtering, we prepare PtOx, which upon partial reduction yields a porous thin-film form of Platinum with favorable...

A drug self-assembly based on Chlorin e6 and BLZ945 is developed to improve the drug stability and delivery efficiency, which can enhance photodynamic immunotherapy through tumor immunogenic induction and tumor-associated macrophage depletion. The self-assembled drug delivery system not only promotes the primary tumor eradication but also improves...

Abstract To solve the problems of slow regeneration and mismatch of axon regeneration after peripheral nerve injury, nerve guidance conduits (NGCs) have been widely used to promote nerve regeneration. Multichannel NGCs have been widely studied to mimic the structure of natural nerve bundles. However, multichannel conduits are prone to structural instability....