Early intensive glycaemic control with sulfonylurea or insulin, or with metformin, compared with conventional glycaemic control, appears to confer a near-lifelong reduced risk of death and myocardial infarction. Achieving near normoglycaemia immediately following diagnosis might be essential to minimise the lifetime risk of diabetes-related complications...

A lack of funds is compounding attacks on health care, for which no one has yet been held to account. By Sharmila Devi.

World inflammatory bowel disease (IBD) Day 2024 unites around the theme IBD has no borders. As a multinational authorship of physicians and people with lived experiences of IBD, we recognise that Crohn's disease and ulcerative colitis extend across both geographical and personal boundaries. Traditionally considered to be a disease of high-income countries...

Increasing numbers of doctors are leaving the specialty or switching to private practice, leaving millions without effective primary care. Paul Webster reports.

There was no benefit and possible harm from treatment with intravenous tenecteplase. Patients with minor stroke and intracranial occlusion should not be routinely treated with intravenous thrombolysis.

Although characterised by mild neurological symptoms, typically ranging from 0 to 5 on the National Institutes of Health Stroke Scale (NIHSS), minor ischaemic stroke is associated with frequent long-term disability and a significant risk of stroke recurrence.1 Research on the treatment of minor stroke has progressed along two parallel paths: acute revascularisation2–4...